Table 2.

Results of the MIC analyses.

ThyPRO scale	Mean score at baseline (s.d.)	Mean change from baseline to follow-up	Smallest possible changea	AUC	ROC-based MIC	Sensitivity %	Specificity %	Cronbach’s alpha	sem	Reliable change index
Goiter symptoms	22 (21.6)	−8.1	2.27	0.72	6.8	69	71	0.92	6.2	11.2
Hyperthyroid symptoms	28 (27.7)	−9.9	3.13	0.67	10.7	55	72	0.84	8.6	15.5
Hypothyroid symptoms	24 (21.8)	−5.2	6.25	0.64	6.3	71	57	0.71	11.7	21.1
Eye symptoms	17 (19.1)	−4.1	3.13	0.76	6.3	68	73	0.86	7.0	12.7
Cognition	25 (23.9)	−5.4	4.17	0.68	6.7	63	69	0.94	6.0	10.9
Tiredness	58 (27.0)	−11.9	3.57	0.85	14.3	80	79	0.94	6.4	11.6
Anxiety	29 (24.1)	−12.0	4.17	0.76	12.5	75	69	0.91	7.4	13.4
Depressivity	33 (22.2)	−1.1	3.57	0.77	7.1	73	70	0.91	6.8	12.3
Emotional susceptibility	39 (24.6)	−9.4	2.78	0.80	11.1	72	72	0.94	6.3	11.4
Impaired daily life	25 (27.1)	−9.1	4.17	0.80	7.5	79	73	0.94	6.9	12.5
Impaired social life	14 (20.2)	−3.6	6.25	0.71	6.3	70	72	0.83	8.2	14.9
Impaired sex life	24 (30.9)	−6.6	12.50	0.68	12.5	66	72	0.90	9.8	17.8
Cosmetic complaints	19 (20.0)	−1.7	4.17	0.65	8.3	54	71	0.82	8.5	15.3
ThyPRO composite QoL	31 (15.8)	−1.7	1.14	0.74	9.1	68	75	0.95	4.4	8.0

^aSmallest possible change in scale score for a single person.

AUC, area under the curve; MIC, minimal important change; ROC, receiver operating characteristics; Qol, quality of life.