Figure 1.

Exercise reduces body weight in high-fat diet-induced obese mice. Male C57BL/6J mice (n = 36) were randomly divided into normal diet group (ND group, n = 14) and high-fat diet group (HFD group, n = 22). After 12-week obesity-induction period, the body weight of all mice was measured and six mice from the ND group and six mice from the HFD group were sacrificed. The remaining mice received 12 weeks of diet and exercise intervention (diet and exercise intervention period): the mice in the ND group (n = 8) were continuously fed the normal diet; the high-fat diet-fed mice were divided into the high-fat diet group (HFD group, n = 8) and the high-fat diet plus exercise group (HFD+EXE group, n = 8). (A) Initial body weight, body weight at the end of obesity-induction period and body weight at the end of diet and exercise intervention period. (B) Body weight measured weekly during the diet and exercise intervention period. Data are presented as the mean ± s.d. For panel A, *P < 0.05; for panel B, *P < 0.05 HFD+EXE vs HFD.