Figure 1.

Expression of DLL3 in MTC with and without desmoplasia and its lymph node metastasis (A). Representative microphotographs of MTC with and without desmoplasia showing in H&E typical morphologic features. Immunohistochemistry for DLL3 shows a strong signal in tumors with desmoplasia as well in primary tumors as in lymphnode metastases. Tumors without desmoplasia are largely negative. (B) Bar chart divided into desmoplasia negative and positive tumors showing DLL3 expression of every single case. (C) Number of DLL3 positive tumor cells is significantly increased dependent on status of metastases and desmoplasia. ***P < 0.0001.