Table 3.
The median survival time from onset of symptoms until the primary end point is calculated in association with ΔFS’ divided into two groups by the 50% quantile, ΔFS’ divided arbitrarily into three groups, and with age divided by the 50% quantile
| Kaplan-Meier survival analysis | Cox proportional hazards | |||||
|---|---|---|---|---|---|---|
| No. of pts. | MST | p (log-rank) | Hazard Ratio | CI | p | |
| ΔFS’ | ||||||
| Group 1, < 0.68 (Slow) | 45 | 46.5 | – | 1 | – | – |
| Group 2, ≥0.68 (Fast) | 45 | 25.2 | 1.3e-7 | 3.66 | 2.17–6.18 | 1.1e-6 |
| ΔFS’ | ||||||
| < 0.5 (Slow) | 29 | 55.5 | – | 1 | – | – |
| 0.5–1.0 (Medium) | 34 | 31.7 | 5.5e-5 | 3.12 | 1.66–5.85 | 3.9e-4 |
| > 1.0 (Fast) | 27 | 19.8 | 0.0032 | 7.50 | 3.71–15.17 | 2.1e-8 |
| Age (yrs) | ||||||
| < 65.2 | 45 | 40.4 | – | 1 | – | – |
| ≥ 65.2 | 45 | 25.9 | 8.0e-4 | 2.18 | 1.34–3.54 | 0.0017 |
CI Confidence interval, ΔFS’ ALSFRS-R progression rate, MST Median survival time (from onset of symptoms until primary endpoint in months), p: p-value, pts. Patients, yrs. Years