Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 16;21:220. doi: 10.1186/s12935-021-01880-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — SHMT2 was overexpressed in OSCC tissues and predicted poor prognosis. a Relative analysis of SHMT2 mRNA in OSCC (n = 313) and adjacent normal tissues (n = 30) from the TCGA database. b Analysis of SHMT2 mRNA level in different pathologic stages of OSCC samples in the TCAG database (stage I, n = 19; stage II, n = 54; stage III, n = 56; stage IV, n = 162). c SHMT2 expression level in 30 paired oral tumor tissues and adjacent normal tissues in the TCGA database. d Kaplan–Meier survival curves for overall survival (n = 312), disease free survival (n = 312) and disease specific survival (n = 295) in OSCC patients with high and low expression of SHMT2. e Immunohistochemistry staining of SHMT2 in ANCT and tumors with different degrees of differentiation. Magnification of 100 × (up) and 400 × (down). f Immunohistochemical staining score of SHMT2 in ANCT (n = 19) and OSCC (n = 91) tissues. g Immunohistochemical staining score of SHMT2 in three different differentiation degrees of OSCC (Well: n = 17, middle: n = 41, poor: n = 33). h Western blot pictures and quantitative analysis of SHMT2 in NOK and TSCC cell lines. i Real time PCR analysis of SHMT2 in NOK and TSCC cell lines. P-values were obtained using Student's t-tests, one-way ANOVA tests, and log-rank tests. All data are shown as mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001. OSCC, oral squamous cell carcinoma; TSCC, tongue squamous cell carcinoma ANCT, adjacent noncancerous tissue samples; NOK, normal oral keratinocyte