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. 2021 Apr 16;21:220. doi: 10.1186/s12935-021-01880-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Knockdown of SHMT2 impaired TSCC invasive, migrative and epithelial mesenchymal transition ability. a Representative photograph of trans-well assays in HN6 and HSC3 cells after transfection with si-RNA. b, c Quantitative analysis of trans-well assays in HN6 and HSC3. d Wound healing assay images of HN6 and HSC3 cells after SHMT2 down-regulation. e, f Quantitative analysis of wound healing assay in HN6 and HSC3. g Western blot analysis images of EMT-related proteins in HN6 and HSC3 cells after SHMT2 knockdown. h, i Quantitative analysis of EMT-related proteins in HN6 and HSC3 transfected with si-RNA. P-values were obtained by Student's t-tests, * p < 0.05, ** p < 0.01, *** p < 0.001. EMT, epithelial mesenchymal transition; E-cad, E-cadherin; N-cad, N-cadherin