Table 1.

Correlations between SHMT2 and clinicopathological characteristics of oral squamous cell carcinoma in TCGA database (n = 96)

Characteristics	SHMT2 expression
	High	Low	p value
Anatomic site
Alveolar Ridge	5	5	0.215
Buccal Mucosa	6	3
Floor of mouth	20	9
Hard palate	0	2
Oral Cavity	11	7
Tongue	12	16
Age (years)
< 61	24	28	0.03*
≥ 61	30	14
Gender
Male	36	30	0.618
Female	18	12
Alcohol history
Yes	32	36	0.005**
No	22	6
Tobacco smoking history
Yes	36	30	0.618
No	18	12
pT stage
T1–2	13	20	0.016*
T3–4	41	22
pN stage
N−	17	20	0.039*
N+	37	22
pM stage
M−	39	34	0.320
M+	15	8
Clinical stage
I–II	8	17	0.004**
III–IV	46	25
Histologic grade
Well	4	10	0.078
Moderately	39	25
Poorly	11	7
Lymph node neck dissection
Yes	52	40	1.000
No	2	2
Lymph vascular invasion
Yes	20	10	0.165
No	34	32
Perineural invasion
Yes	26	23	0.520
No	28	19
Close or positive margin
Yes	22	9	0.045*
No	32	33
Recurrence
Yes	21	10	0.117
No	33	32

pT stage pathologic T stage, pN stage pathologic N stage, pM stage pathologic M stage

^*represents P < 0.05, **represents P < 0.01, ***represents P < 0.001