Table 2.
The GO terms enrichment for the co-DEGs of septic shock and AKI
| Gene/product | GO class (direct) | Evidence | Reference |
|---|---|---|---|
| VMP1 | protein binding | IPI | PMID:17724469 |
| endoplasmic reticulum | IDA | GO_REF:0000052 | |
| autophagosome assembly | IMP | PMID:30093494 | |
| SLPI | protein binding | IPI | PMID:12526812 |
| antibacterial humoral response | ISS | GO_REF:0000024 | |
| extracellular space | IDA | PMID:18714013 | |
| collagen-containing extracellular matrix | HDA | PMID:28675934 | |
| innate immune response | ISS | GO_REF:0000024 | |
| modulation of process of other organism | IDA | PMID:2467900 | |
| negative regulation of endopeptidase activity | IEA | GO_REF:0000108 | |
| serine-type endopeptidase inhibitor activity | IDA | PMID:3462719 | |
| PTX3 | protein binding | IPI | PMID:19050261 |
| complement component C1q complex binding | IDA | PMID:23544079 | |
| extracellular region | TAS | Reactome:R-HSA-6798745 | |
| extracellular space | IDA | PMID:23544079 | |
| innate immune response | IDA | PMID:23544079 | |
| TIMP1 | protein binding | IPI | PMID:16917503 |
| extracellular region | TAS | Reactome:R-HSA-1602454 | |
| metalloendopeptidase inhibitor activity | IDA | PMID:12714508 | |
| basement membrane | IEA | GO_REF:0000107 | |
| cytokine-mediated signaling pathway | TAS | Reactome:R-HSA-6783783 | |
| extracellular space | IDA | PMID:3903517 | |
| negative regulation of endopeptidase activity | IDA | PMID:3903517 | |
| negative regulation of membrane protein ectodomain proteolysis | IDA | PMID:12714508 | |
| OLFM4 | protein binding | IPI | PMID:20534456 |
| extracellular exosome | HDA | PMID:19056867 | |
| extracellular space | HDA | PMID:16502470 | |
| extracellular region | TAS | Reactome:R-HSA-6798745 | |
| plasma membrane | IDA | GO_REF:0000052 | |
| LCN2 | protein binding | IPI | PMID:32296183 |
| extracellular region | ISS | GO_REF:0000024 | |
| extracellular space | HDA | PMID:16502470 | |
| extracellular exosome | HDA | PMID:19056867 | |
| iron ion binding | ISS | GO_REF:0000024 | |
| S100A9 | protein binding | IPI | PMID:17620599 |
| extracellular region | TAS | PMID:22489132 | |
| collagen-containing extracellular matrix | HDA | PMID:23979707 | |
| extracellular space | HDA | PMID:16502470 | |
| cytosol | IDA | GO_REF:0000052 | |
| extracellular exosome | HDA | PMID:19056867 | |
| antimicrobial humoral immune response mediated by antimicrobial peptide | IDA | PMID:12874352 | |
| calcium ion binding | TAS | PMID:22489132 | |
| cytoplasm | IDA | PMID:12874352 | |
| leukocyte migration involved in inflammatory response | IDA | PMID:12626582 | |
| neutrophil aggregation | IDA | PMID:12626582 | |
| neutrophil chemotaxis | IDA | PMID:12626582 | |
| nucleus | HDA | PMID:21630459 |
IPI physical interaction evidence used in manual assertion, IDA direct assay evidence used in manual assertion, ISS sequence similarity evidence used in manual assertion, IEA evidence used in automatic assertion, TAS traceable author statement used in manual assertion, IMP mutant phenotype evidence used in manual assertion, HAD high throughput direct assay evidence used in manual assertion