Table 2.
Breast cancer risk factors and antibiotic use in patients recruited at the Cleveland Clinic
| Variable | Cancer (n = 48) |
High-risk (n = 7) |
Healthy control (n = 11) |
p-value |
|---|---|---|---|---|
| Age at menarche (years) | 13 (12–13) | 12 (12–13) | 11 (10–12) | 0.230 |
| Postmenopausal | 28 (58%) | 5 (71%) | 4 (36%) | 0.367 |
| Gravity/parity | 2 (1–3.8)/2 (1–3) | 2 (1–3)/2 (0–3) | 1.5 (0–2.5)/1 (0–2.3) | 0.309/0.397 |
| OCP or HRT usea | 33 (69%) | 6 (100%) | 4 (57%) | 0.248 |
| Family history of breast cancera | 26 (54%) | 4 (67%) | 0 (0%) | 0.001 |
| Alcohol usea | 0.421 | |||
| Frequent | 19 (40%) | 2 (28.5%) | 4 (40%) | |
| Occasional | 12 (25%) | 2 (28.5%) | 5 (50%) | |
| None | 17 (35%) | 3 (43%) | 1 (10%) | |
| Last oral antibiotic usea | 0.985 | |||
| < 1 month ago | 6 (17%) | 1 (17%) | 2 (20%) | |
| 1–6 months ago | 12 (34%) | 2 (33%) | 4 (40%) | |
| > 6 months ago | 17 (49%) | 3 (50%) | 4 (40%) |
Data are presented as number of patients (%) or median (interquartile range)
aMissing data: OCP or HRT use (n = 5), family history (n = 1), alcohol use (n = 1), and antibiotic use (n = 15). Percentages are calculated from the total number of patients with known values
OCP, oral contraceptive pill; HRT, hormone replacement therapy