Table 4.
Comparison of Green Tea-Associated Liver Injury in Patients with One versus Two Copies of HLA-B*35:01
| Feature | One Copy of HLA-B*35:01 n=22 | Two Copies of HLA-B*35:01 n=4 |
|---|---|---|
| Age | 38 (17–69) | 42 (34–48) |
| Female Sex | 18 (82%) | 3 (75%) |
| Race: White | 16/21 (76%) | 2 (50%) |
| Hispanic Ethnicity | 7 (32%) | 2 (50%) |
| Body Mass Index | 28.1 (20.5–42.4) | 25.4 (20.6–40.7) |
| Time to Onset | 66 (22–335) | 69 (39–376) |
| Initial ALT | 2364 (968–4185) | 1810 (836–2701) |
| Initial alkaline phosphatase | 152 (80–550) | 255 (117–391) |
| Initial total bilirubin | 9.3 (0.4–22.0) | 6.7 (3.3–11.6) |
| Peak total bilirubin | 13.0 (0.6–38.2) | 14.8 (3.7–26.7) |
| Peak INR | 1.2 (1.0–7.0) | 1.2 (1.0–1.8) |
| Initial R ratio | 29.9 (7.5–67) | 17.6 (10.0–35.7) |
| Hepatocellular | 22 (100%) | 4 (100%) |
| Rash or Fever | 7 (32%) | 0 |
| ANA or SMA | 9 (41%) | 2 (50%) |
| Severity Score | ||
| Liver Transplant | 2 (9%) | 0 |
| Chronicity | 0/18 | 0/3 |
| Heterozygous | Homozygous |
All results are median (range) or number (proportion) with denominator given if there were missing data. None of the differences were statistically significant.