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. Author manuscript; available in PMC: 2022 Mar 11.
Published in final edited form as: J Med Chem. 2021 Feb 17;64(5):2777–2800. doi: 10.1021/acs.jmedchem.0c02070

Table 2.

Structures and inhibitory activities of compounds 19–24.a

graphic file with name nihms-1690295-t0021.jpg
Compd. R2 Heterocycle IC50 (μM)
19 graphic file with name nihms-1690295-t0022.jpg graphic file with name nihms-1690295-t0023.jpg 3.7
20 graphic file with name nihms-1690295-t0024.jpg graphic file with name nihms-1690295-t0025.jpg 10.7
21 graphic file with name nihms-1690295-t0026.jpg graphic file with name nihms-1690295-t0027.jpg 2.1
22 graphic file with name nihms-1690295-t0028.jpg graphic file with name nihms-1690295-t0029.jpg 9.3
23 graphic file with name nihms-1690295-t0030.jpg graphic file with name nihms-1690295-t0031.jpg 19.3
24 graphic file with name nihms-1690295-t0032.jpg graphic file with name nihms-1690295-t0033.jpg 3.5
a

Standard errors of all IC50 values are less than 30%.