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. Author manuscript; available in PMC: 2022 Mar 11.
Published in final edited form as: J Med Chem. 2021 Feb 17;64(5):2777–2800. doi: 10.1021/acs.jmedchem.0c02070

Table 8.

Structures and inhibitory activities of compounds 84–104.a

graphic file with name nihms-1690295-t0140.jpg
Compd. R6 IC50 (μM) Compd. R6 IC50 (μM)
84 graphic file with name nihms-1690295-t0141.jpg >10 95 graphic file with name nihms-1690295-t0142.jpg >10
85 graphic file with name nihms-1690295-t0143.jpg 8.4 96 graphic file with name nihms-1690295-t0144.jpg 2.5
86 graphic file with name nihms-1690295-t0145.jpg 1.9 97 graphic file with name nihms-1690295-t0146.jpg >10
87 graphic file with name nihms-1690295-t0147.jpg 17.1 98 graphic file with name nihms-1690295-t0148.jpg 16.2
88 graphic file with name nihms-1690295-t0149.jpg 10.6 99 graphic file with name nihms-1690295-t0150.jpg 3.1
89 graphic file with name nihms-1690295-t0151.jpg 8.0 100 graphic file with name nihms-1690295-t0152.jpg 2.9
90 graphic file with name nihms-1690295-t0153.jpg 1.8 101 graphic file with name nihms-1690295-t0154.jpg 0.65
91 graphic file with name nihms-1690295-t0155.jpg 13.0 102 graphic file with name nihms-1690295-t0156.jpg 1.0
92 graphic file with name nihms-1690295-t0157.jpg >10 103 graphic file with name nihms-1690295-t0158.jpg 0.13
93 graphic file with name nihms-1690295-t0159.jpg 3.5 104 graphic file with name nihms-1690295-t0160.jpg >10
94 graphic file with name nihms-1690295-t0161.jpg 0.59
a

Standard errors of all IC50 values are less than 30%.