➢ The HACCP implementation is based on 7 principles:

1 Hazard analysis (causes, preventive measures)

2 Identification of critical control points (CCP)

3 Establishment of target values and tolerances for each CCP (critical limits)

4 Establishment of a monitoring system for each CCP

5 Establishment of corrective actions

6 Verification

7 Establishment of documentation

➢ The OPERA method (Tool for the First Assessment Analysis Risk by Activities) (Burgundy Franche Comte, 2008). The OPERA method is a preliminary evaluation tool of chemical risks that can be completed by a metrology. It assesses the risks in health and safety at work and fire by taking into account the actual business operators. It allows an overall assessment of chemical risks to the position and/or prioritization of different work phases. It helps to prioritize the axis of action to helping the definition of preventive measures to be implemented. Moreover, this method allows a predictive risk assessment in case of process choise modification for a same product or of product modification.

➢ The OPERA-HACCP approach, which we propose, is based on 12 steps including 7 principles (Rachidi et al. 2016a):

1 Constitution of the team HACCP-OPERA: It is essential that the host of the HACCP-OPERA team sets up a working group bringing together the various stakeholders, occupational health service, medical profession…

2 Inventory and description of products, personnel, and environment work: This is the most important step; it consists the following:

2.1 To identify and collect data on all chemicals used, generated, or stored in workstations, and classify and view their properties. Also, expired or unused products for some time will be removed by procedures that respect the environment;

2.2 To describe the personnel, workstations, and collective and personal protective equipment.

3 Determination of the intended use of the products: identifying the intended use of the product, where it draws up the conditions of storage and use of the products by the operator;

4 Establishment of the list of operations: The list of operations shall be established and the team should investigate the possibilities of risk exposure, accidents, and incidents, based on statistics of diseases and injuries and their analyses;

5 Confirmation of the list of operations instantly;

6 Analysis of dangers and preventive measures (principle 1):

6.1 Hazard identification: The list of operations shall be established, and the team should investigate the possibilities of risk exposure, accidents, and incidents, based on statistics of diseases and injuries and their analyses;

6.2 Identification of possible damage;

6.3 Identification of preventive measures: identifying preventive measures to eliminate the risk or reduce its occurrence to an acceptable level.