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. 2021 Mar 27;49(7):4085–4103. doi: 10.1093/nar/gkab190

Figure 2.

Figure 2.

CLASH rRFs originated from multiple regions across 45S pre-rRNA. The number of identified rRFs covering every nucleotide of human 45S pre-rRNA (GenBank U13369.1) is plotted along the length of 45S. Pale red, green and blue boxes correspond to the 18S, 5.8S and 28S mature rRNAs, respectively. Gray boxes correspond to the ITS domains. Red vertical lines indicate the endonucleolytic cleavage sites (92). Arrows indicate borders of two largest expansion segments in 28S rRNAs, absent from E. coli and present in human (57).