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Phosphorylation of BAF by VRK1 greatly reduces its affinity for dsDNA. Fluorescence experiments revealed that the affinity of BAF WT for a coated 48 nt dsDNA is 2.5 ± 1 nM, whereas the affinity of pBAF for this same dsDNA is 11 ± 2 μM. Binding curves of BAF variants S4E and A12T are displayed in Supplementary Figure S4 and all affinities are summarized in Table 1.
