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. 2020 Nov 3;70(5):1343–1350. doi: 10.1007/s00262-020-02767-6

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© The Author(s) 2020

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Fig. 2 — Impact of ICB therapy on expression patterns of instructive cytokines in TIDCs. a, b Typical result of intracellular staining of IL-12 and IL-10 in CD11c⁺ spleen cells. Similar patterns were detected in CD11c^low and CD11c^high cells. c Compilation of IL-12/IL-10 ratios in TIDCs from animals that received ICB therapy or were left untreated. In some animals, ICB was combined with neutralization of IFN-γ using the mAb XMG-1.2. Up to 14 mice were used per group. d Percentages of IFN-γ⁺ cells in the CD4⁺ T-cell population from spleens of the indicated mouse groups. 4–5 mice were included in each group. The difference between the ICB-treated group and all other settings is significant with P < 0.01. In the CD8⁺ subset, the effect of ICB in terms of IFN-γ induction was far less pronounced [12]