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. 2020 Nov 3;70(5):1343–1350. doi: 10.1007/s00262-020-02767-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Direct interaction of anti-PD-1 and anti-CTLA-4 mAbs with DCs. a, b Exemplary results showing higher levels of PD-1 and CTLA-4 expressed on λ-MYC TIDCs than on DCs from WT mice. c IL-12/IL-10 ratios in purified CD11c⁺ cells with or without incubation with ICB mAbs for 72 h in vitro (n = 5). Identical results were obtained in CD11c^low and CD11c^high cells