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. 2020 Nov 2;70(5):1277–1289. doi: 10.1007/s00262-020-02750-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Granzyme B in peripheral blood mononuclear cells (GrB-PBMC) in malignancy and paraneoplastic neurological syndromes (PNS). a Schematic of an experimental procedure to isolate PBMC and measure GrB-PBMC in study groups. b GrB-PBMC in patients with nonmalignant lesions (nonmalignant ovarian tumors and leiomyomas), malignant tumors (collectively ovarian and lung), and PNS. c GrB-PBMC in patients with PNS with and without onconeural antibodies detected in serum. d GrB-PBMC in patients with PNS that clinically affected either the peripheral or central nervous system. e GrB-PBMC in patients with paraneoplastic peripheral neuropathy and paraneoplastic cerebellar degeneration (PCD). The central line corresponds to the median. The upper and lower “hinges” correspond to the first and third quartiles. P values are denoted as asterisks: ns—p > 0.05, *p < 0.05; **p < 0.01; ***p < 0.001, ****p < 0.0001. A statistical test is specified in the text