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. 2020 Nov 4;70(5):1365–1378. doi: 10.1007/s00262-020-02776-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Representative images of S100A8 expression in breast cancer. a Tumor cells show strong cytoplasmic expression of S100A8 in an invasive breast carcinoma. S100A8-postive immune cells are rarely found in the stromal area. b In this case of invasive breast carcinoma, S100A8-positive immune cells are frequently observed, whereas the tumor cells are totally negative for S100A8. c In a case of high-grade ductal carcinoma in situ with comedo-type necrosis, the tumor cells show strong S100A8 expression. d In this case of ductal carcinoma in situ, abundant S100A8-positive immune cells are found in association with numerous tumor-infiltrating lymphocytes. The tumor cells are negative for S100A8 expression