Table 2.
Univariate and multivariate analyses of disease-specific survival in invasive carcinoma
| Variable | Category | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | p value | Hazard ratio (95% CI) | p value | ||
| Age | < 50 years vs. ≥ 50 years | 0.818 (0.407–1.664) | 0.572 | – | – |
| T stage | T1 vs. T2–4 | 2.193 (1.014–4.743) | 0.046 | 1.377 (0.615–3.083) | 0.437 |
| N stage | N0 vs. N1–N3 | 3.187 (1.474–6.895) | 0.003 | 2.761 (1.184–6.437) | 0.019 |
| Histologic grade | I and II vs. III | 2.644 (1.223–5.716) | 0.013 | 1.527 (0.612–3.811) | 0.364 |
| LVI | Absent vs. present | 3.280 (1.517–7.091) | 0.003 | 2.342 (1.008–5.444) | 0.048 |
| Hormone receptor | Negative vs. positive | 0.369 (0.184–0.738) | 0.005 | 0.390 (0.186–0.820) | 0.013 |
| HER2 | Negative vs. positive | 1.158 (0.520–2.579) | 0.719 | – | – |
| Ki-67 index | Low vs. high | 2.058 (1.016–4.167) | 0.045 | 0.822 (0.324–2.086) | 0.680 |
| S100A8+ TCs | Negative vs. positive | 2.594 (1.290–5.215) | 0.007 | 1.594 (0.736–3.452) | 0.237 |
| S100A8+ ICs | Negative vs. positive | 3.017 (1.396–6.522) | 0.005 | 2.345 (1.034–5.316) | 0.041 |
CI confidence interval, LVI lymphovascular invasion, TC tumor cell, IC immune cell