Fig. 4.

MRI-based segmentation in human melanoma patients treated with an immune checkpoint inhibitor. Representative example for Dixon-based whole-body segmentation of a 64-year-old melanoma patient with PD-1-mAbs therapy at baseline (a) and with progressive disease after 3 months of CIT (b), axial slices of the lumbar region are given. Fat and water MRI images (top row) as well as delineated segments of visceral adipose tissue (VAT, bottom left with VAT indicated in red) and subcutaneous adipose tissue (SCAT, bottom right with SCAT indicated in blue) are shown. Total fat was reduced by − 26% after 12 weeks, body weight was reduced by − 7.2%