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. 2020 Nov 1;70(5):1263–1275. doi: 10.1007/s00262-020-02765-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Representative examples of MRI-based whole-body segmentation and treatment-associated changes in metastatic melanoma patients treated with an immune checkpoint inhibitor. a, b Quantitative MRI measurements of visceral adipose tissue (VAT, top), subcutaneous adipose tissue (SCAT, middle) and lean tissue water (LTW, bottom) distribution in melanoma patients treated with CIT (n = 16). Examples for a melanoma patient with progressive disease (PD, a, same patient as in Fig. 4) and response to treatment (RTT, B) are given. Graphs show measurements at baseline and 2 weeks and 12 weeks into treatment outlined as the craniocaudal distribution. c Bar charts with percent change in body composition after 12 weeks of CIT therapy relative to baseline. The percent change in visceral adipose tissue (VAT), subcutaneous adipose tissue (SCAT) and lean tissue water (LTW) from baseline to the last measurement, stratified by therapeutic response, are given. No significant changes were present between groups for VAT and SCAT. Significant group differences were present for LTW (F = 9.05, p = 0.0034)