Table 1.

Group differences in regions showing significant connectivity to the PCC and ACC seeds.

			Talairach Coordinates			p *
	Region	BA	x	y	z	PCC	ACC
	Both PCC and ACC
L	superior frontal gyrus	10	−22	56	11	0.0435	0.3528
L	superior frontal gyrus	8	−20	26	47	0.0005	0.0432
R	superior frontal gyrus	8	25	30	45	0.0006	0.0439
L	middle frontal gyrus	6	−38	10	50	0.0093	0.3745
L	inferior frontal gyrus	47	−42	28	−10	0.0002	0.0007
R	inferior frontal gyrus	47	39	28	−12	0.0008	0.0260
L	medial frontal gyrus	9	−4	53	20	7.7×10 −6	0.0001
R	medial frontal gyrus	9	5	46	25	0.0008	0.0125
L	medial frontal gyrus	8	−6	45	43	0.0020	0.0061
L	insula, posterior	13	−35	−19	20	0.9018	0.2097
R	anterior cingulate	32	8	38	15	6.9×10 −5	0.0510
R	posterior cingulate	23	5	−50	19	0.1202	0.0024
L	angular gyrus	39	−41	−61	29	0.0263	0.0011
R	angular gyrus	39	52	−61	27	0.5147	0.0288
L	middle temporal gyrus	21	−56	−3	−16	0.0012	0.0200
R	middle temporal gyrus	21	56	−4	−19	0.0016	0.0582
L	inferior temporal gyrus	20	−49	7	−24	0.0002	0.0015
R	cerebellum, lobule 7		21	−81	−28	1.6×10 −5	0.0001
	PCC only
L	anterior cingulate	32	−5	41	14	6.1×10 −5
L	hippocampus		−25	−17	−10	0.0006
R	hippocampus		24	−15	−14	0.0022
L	parahippocampal gyrus	35	−27	−34	−11	0.0618
L	precuneus	31	−2	−61	25	0.0747
R	precuneus	31	6	−58	27	0.6664
L	cerebellum, lobule 7		−34	−76	−28	0.0081
	ACC only
L	superior frontal gyrus	9	−12	48	33		0.0020
L	middle frontal gyrus	9	−45	17	34		0.0100
R	middle frontal gyrus	46	42	47	6		0.0330
R	middle frontal gyrus	10	25	51	9		0.7039
R	middle frontal gyrus	6	30	7	54		0.1178
L	inferior frontal gyrus	45	−51	22	8		0.1846
L	inferior frontal gyrus**	13	−39	21	4		0.0035
R	inferior frontal gyrus**	13	37	21	9		0.0011
L	insula, anterior	13	−33	3	13		0.0103
L	posterior cingulate	23	−2	−51	23		3.5×10 −5
L	lingual gyrus	18	−4	−83	−2		0.0184
L	caudate		−11	13	8		0.0899
R	caudate		14	17	7		0.1580
L	putamen		−20	10	8		0.0111
R	putamen**		23	11	6		0.0008
L	thalamus		−6	−12	10		0.2636

^*Results of paired Student’s t-tests between groups. Values in bold survived the FDR correction.

^**Regions where connectivity is stronger in DS as compared to controls.