Table 3.
Change in variables from baseline at 3 months after Roux-en-Y gastric bypass (malabsorptive) and sleeve gastrectomy (restrictive) surgery
| Variable | Sleeve gastrectomy (n = 14) | Roux-en-Y gastric bypass (n = 27) | ||||
|---|---|---|---|---|---|---|
| Before surgery | After surgery | p | Before surgery | After surgery | p | |
| BMI (kg/m2) | 46.9 ± 10.1 | 39 ± 8.2 | 0.0001 | 44.8 ± 4.5 | 36.9 ± 3.9 | 0.0001 |
| Glucose (mg/dl) | 92.3 ± 22.2 | 94.5 ± 16 | 0.8 | 131.1 ± 37.1 | 104.1 ± 14.8 | 0.004 |
| Insulin (mIU/l) | 15.1 (11.8–21.8) | 8.3 (4.3–12.0) | 0.009 | 19.2 (12.8–27.6) | 10.1 (7.5–14.3) | 0.001 |
| HOMA2- IR | 2.3 (1.6–3.0) | 1.2 (0.8–1.9) | 0.12 | 3.1 (2.1–4.3) | 1.5 (1.1–2.2) | 0.0003 |
| NEFA | 0.73 ± 0.34 | 0.78 ± 0.2 | 0.57 | 0.8 ± 0.35 | 0.72 ± 0.33 | 0.47 |
| ADIPO-IR | 118.2 ± 80.2 | 92 ± 81.4 | 0.68 | 107.3 ± 77.6 | 51.8 ± 9.1 | 0.005 |
| Hb1Ac | 6.2 ± 1 | 5.3 ± 0.94 | 0.007 | 7.7 ± 2.0 | 6.2 ± 0.8 | 0.0007 |
| Apo A-I (mg/dl) | 117.5 ± 21.3 | 135.5 ± 25.7 | 0.06 | 103.5 ± 23.1 | 127.8 ± 18.6 | 0.006 |
| Male | 122.3 ± 32.1 | 133.5 ± 14.0 | 0.09 | 106.7 ± 13.1 | 123.3 ± 18.5 | 0.01 |
| Female | 111.3 ± 14.8 | 137.5 ± 28.2 | 0.04 | 102.8 ± 25.0 | 126.8 ± 19.0 | 0.002 |
| Apo B (mg/dl) | 87.8 ± 20.4 | 103.8 ± 19.1 | 0.02 | 75.4 ± 17.0 | 99.2 ± 16.5 | 0.001 |
| TC (mg/dl) | 193.2 ± 80.9 | 176.8 ± 34.6 | 0.35 | 163.1 ± 22.9 | 160.7 ± 22.6 | 0.66 |
| HDL-C (mg/dl) | 43.9 ± 11.1 | 42.3 ± 5.2 | 0.53 | 42.1 ± 9.3 | 37 ± 5.9 | 0.017 |
| Male | 41.7 ± 8.0 | 41.3 ± 5.0 | 0.92 | 39.3 ± 7.3 | 31.5 ± 4.2 | 0.03 |
| Female | 45.5 ± 12.7 | 42.6 ± 6.0 | 0.44 | 42.6 ± 9.7 | 38.2 ± 5.6 | 0.04 |
| LDL-C (mg/dl) | 103.5 ± 26.6 | 116.1 ± 33.0 | 0.12 | 99.5 ± 26.2 | 97.5 ± 29.4 | 0.74 |
| TG (mg/dl) | 146.9 ± 51.1 | 116.5 ± 36.9 | 0.009 | 137.6 ± 35.9 | 122.1 ± 48.7 | 0.14 |
| VLDL-C (mg/dl) | 26.6 ± 11.7 | 21.9 ± 8.7 | 0.16 | 24.6 ± 9.3 | 23.1 ± 9.6 | 0.5 |
| CEC (A.U.) | 0.89 ± 0.1 | 1.03 ± 0.18 | 0.012 | 0.92 ± 0.14 | 1.0 ± 0.14 | 0.006 |
| Adiponectin (µg/ml) | 6.0 ± 1.3 | 7.7 ± 1.5 | 0.001 | 5.4 ± 2.4 | 6.7 ± 2.7 | 0.02 |
| Log resistin | 2.4 ± 0.7 | 1.9 ± 0.67 | 0.06 | 2.3 ± 0.16 | 2.0 ± 0.78 | 0.09 |
| Log MCP-1 | 1.6 ± 0.4 | 1.6 ± 0.47 | 0.97 | 1.9 ± 0.41 | 1.6 ± 0.53 | 0.08 |
| IL-10 (pg/ml) | 0.1 (0.01–0.44) | 0.2 (0.12–0.56) | 0.62 | 0.33 (0.1–0.8) | 0.2 (0.11–0.54) | 0.21 |
| TNF-alpha (pg/ml) | 2 ± 0.8 | 3 ± 1.4 | 0.05 | 2.5 ± 2.2 | 2.2 ± 1.3 | 0.6 |
Data expressed as mean ± standard deviation or median (interquartile range)
BMI body mass index, HOMA2-IR homeostatic model assessment method-insulin resistance, NEFA non-esterified fatty acids, Adipo-IR adipose tissue-insulin resistance, HbA1c glycated hemoglobin, Apo A-I apolipoprotein A-I, Apo B apolipoprotein B, TC total cholesterol, HDL-C high density lipoprotein-cholesterol, LDL-C low density lipoprotein-cholesterol, VLDL-C very low density lipoprotein-cholesterol, TG triglycerides, CEC cholesterol efflux capacity, MCP-1 monocyte chemoattractant protein-1, IL-10 interleukin 10, TNF-alpha tumor necrosis factor-alpha