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. Author manuscript; available in PMC: 2021 Apr 18.
Published in final edited form as: Am J Clin Pathol. 2011 Jul;136(1):119–127. doi: 10.1309/AJCP03HUQYZMWATP

Image 1.

Image 1

A, Cervical intraepithelial neoplasia (CIN) 1 with mild dysplasia and human papillomavirus (HPV) cytopathic effect with diffuse signal pattern of HPV staining (NBT/BCIP substrate with nuclear fast red counterstain, ×100). B, CIN 2 with moderate dysplasia and HPV cytopathic effect with diffuse signal pattern of HPV staining (NBT/BCIP substrate with nuclear fast red counterstain, ×400). C, Endocervical adenocarcinoma. In situ hybridization is positive for high-risk HPV types in rare adenocarcinoma cells and negative in benign endocervical glands. There is moderate dysplasia and HPV cytopathic effect with diffuse signal pattern of HPV staining (NBT/BCIP substrate with nuclear fast red counterstain, ×400).