Table 3.
Associations in Histologic Diagnosis, LBC, CPE, and HPV+ Testing by ISH vs PCR*
| Cervical Biopsy Result | ||||||
|---|---|---|---|---|---|---|
| Results | Negative | CIN 1 | CIN 2 | CIN 3 | Adenocarcinoma | Total |
| LBC | ||||||
| Negative | 44 (9) | 2 (4) | 1 (2) | 0 (0) | 0 (0) | 47 (100) |
| ASCUS | 13 (30) | 17 (39) | 10 (23) | 2 (5) | 2 (5) | 44 (100) |
| LSIL | 13 (19) | 45 (66) | 9 (13) | 1 (1) | 0 (0) | 68 (100) |
| HSIL | 0 (0) | 4 (29) | 6 (43) | 3 (21) | 1 (7) | 14 (100) |
| Adenocarcinoma | 0 (0) | 0 (0) | 0 (0) | 1 (33) | 2 (67) | 3 (100) |
| Total | 70 (39.8) | 68 (38.6) | 26 (14.8) | 7 (4.0) | 5 (2.8) | 176 (100.0) |
| CPE | ||||||
| Absent | 34 (65) | 6 (12) | 4 (8) | 4 (8) | 4 (8) | 52 (100) |
| Present | 36 (29.0) | 62 (50.0) | 22 (17.7) | 3 (2.4) | 1 (0.8) | 124 (100.0) |
| Total | 70 (39.8) | 68 (38.6) | 26 (14.8) | 7 (4.0) | 5 (2.8) | 176 (100.0) |
| ISH | ||||||
| Positive | 22 (18.8) | 61 (52.1) | 23 (19.7) | 7 (6.0) | 4 (3.4) | 117 (100.0) |
| Negative | 48 (81) | 7 (12) | 3 (5) | 0 (0) | 1 (2) | 59 (100) |
| Total | 70 (39.8) | 68 (38.6) | 26 (14.8) | 7 (4.0) | 5 (2.8) | 176 (100.0) |
| PCR for HPV in LBC samples | ||||||
| Negative | 51 (69) | 16 (22) | 6 (8) | 0 (0) | 1 (1) | 74 (100) |
| Low-risk HPV | 4 (44) | 4 (44) | 0 (0) | 1 (11) | 0 (0) | 9 (100) |
| High-risk HPV | 14 (18) | 36 (46) | 19 (24) | 5 (6) | 4 (5) | 78 (100) |
| Unknown-risk HPV | 1 (7) | 11 (79) | 1 (7) | 1 (7) | 0 (0) | 14 (100) |
| Total | 70 (40.0) | 67 (38.3) | 26 (14.9) | 7 (4.0) | 5 (2.9) | 175 (100.0) |
ASCUS, atypical squamous cells of undetermined significance; CIN, cervical intraepithelial neoplasia; CPE, cytopathic effect; HSIL, high-grade squamous intraepithelial lesion; HPV, human papillomavirus; ISH, in situ hybridization; LBC, liquid-based cytology; LSIL, low-grade squamous intraepithelial lesion; PCR, polymerase chain reaction.
*
Data are given as number (percentage).