Table 4.
Sensitivity, Specificity, PPV, and LRs of the Various Methods*
| CIN 2 or Worse | ||||||
|---|---|---|---|---|---|---|
| Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | PLR (%) | NLR (%) | |
| LBC | ||||||
| ASCUS or worse | 97.4 (87.5–99.5) | 33.3 (30.6–33.9) | 28.7 (25.8–29.3) | 97.9 (89.9–99.6) | 1.5 (1.3–1.5) | 0.079 (0.01–0.41) |
| LSIL or worse | 57.9 (43.9–70.9) | 55.1 (51.2–58.7) | 26.2 (19.9–32.1) | 82.6 (76.8–88) | 1.3 (0.9–1.7) | 0.77 (0.5–1.1) |
| HSIL or worse | 34.2 (24.5–40.3) | 97.1 (94.4–98.8) | 76.5 (54.7–90.1) | 84.3 (81.9–85.7) | 11.8 (4.4–33.2) | 0.68 (0.6–0.8) |
| ISH + | ||||||
| All | 89.5 (77.4–95.7) | 39.9 (36.5–41.6) | 29.1 (25.1–31.1) | 93.2 (85.4–97.3) | 1.5 (1.2–1.6) | 0.26 (0.1–0.62) |
| High-risk HPV only | 89.5 (77.3–95.7) | 45.7 (42.3–47.4) | 31.2 (27–33.4) | 94 (87.1–97.6) | 1.6 (1.3–1.8) | 0.23 (0.09–0.54) |
| HPV PCR + | ||||||
| All | 94.7 (83.8–98.5) | 52.2 (49.2–53.2) | 35.3 (31.2–36.7) | 97.3 (91.7–99.2) | 1.9 (1.6–2.1) | 0.1 (0.03–0.33) |
| Types 16, 18, 31, and 33 | 73.7 (63.7–78.7) | 97.8 (95.1–99.2) | 90.3 (78.1–96.4) | 93.1 (90.5–94.4) | 33.9 (12.9–98.3) | 0.27 (0.22–0.38) |
ASCUS, atypical squamous cells of undetermined significance; CIN, cervical intraepithelial neoplasia; HPV, human papillomavirus; HSIL, high-grade squamous intraepithelial lesion; ISH, in situ hybridization; LSIL, low-grade squamous intraepithelial lesion; NLR, negative likelihood ratio; NPV, negative predictive value; PCR, polymerase chain reaction; PLR, positive likelihood ratio; PPV, positive predictive value.
*
Values in parentheses are 95% confidence intervals.