Figure 3.

Number of times each miRNA was found differentially expressed, when performing a repeated 5-fold nested cross-validation for 100 times with different fold splits. In each step of the outer cross-validation loop, four of the five folds were used to identify differentially expressed miRNAs. Since one outer loop consists of five steps, and we performed 100 repetitions, 500 sets of miRNAs were computed for each pairwise comparison between groups, respectively: control vs presymptomatic, control vs patient and presymptomatic vs patient. MiRNAs from the signature computed with the entire data set are highlighted. miRNA, microRNA.