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. 2020 Nov 18;80(5):651–659. doi: 10.1136/annrheumdis-2020-218881

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Clustering analysis of the centromere antigens and individuals. The sera of patients with SS (n=86), SSc (n=35), PBC (n=10), or overlap disease (n=42), and HC (n=68) were analysed by the antigen-binding bead assay. The serum antibody positivity for each target antigen (rows) in each individual (columns) is indicated by the appropriate colour. Hierarchical clustering produced a dendrogram among target antigens (left) and individuals (bottom). Coloured lines below the matrix indicate the disease status of the individuals. HC, healthy controls; PBC, primary biliary cholangitis; SS, Sjögren’s syndrome;SSc, systemic sclerosis.