Table 1.

Clinical characteristics of the patients who underwent serum analysis

Disease type	HC n=68	SS n=86	SSc n=35	PBC n=10	Overlap n=42
Female %	82	97	86	100	100
Age (y), median (IQR)	44 (31–50)	61 (47–72)	59 (50–71)	60 (56–72)	64 (55–74)
ANA discrete-speckled %	NA	10	34	30	69
Anti-CENP-B antibody positive %	1.5	10	37	30	71
Disease specific antibody positive %		Anti-SSA 83 Anti-SSB 42	Anti-Topo 1 31 Anti-RNAPIII 6	AMA 80
Disease type/ complicated disease %		Primary SS 85 Secondary SS 15	lcSSc 71 dcSSc 29		SS+SSc 27 SS+PBC 17 SSc+PBC 29 SS +SSc+ PBC 29

ACA, anti-centromere antibody; AMA, anti-mitochondrial antibody; dcSSc, diffuse cutaneous systemic sclerosis; HC, healthy controls; lcSSc, limited cutaneous systemic sclerosis; NA, not assessed; PBC, primary biliary cholangitis; RNAPIII, RNA polymerase III; SS, Sjögren’s syndrome; SSc, systemic sclerosis; Topo 1, topoisomerase 1.