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. 2021 Jan 15;92(5):494–501. doi: 10.1136/jnnp-2020-323541

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Cascade of biomarker changes in FTD-GRN along with the uncertainty associated with it. (A) Non-imaging biomarkers. (B) Multimodal biomarkers with Siamese GMM. (C) Multimodal biomarkers without Siamese GMM. The biomarkers are ordered based on the position in the estimated cascade. The colour map is based on the number of times a biomarker is at a position in 100 repetitions of bootstrapping. FTD-GRN, progranulin-related frontotemporal dementia; GMM, Gaussian mixture modelling.