Figure 4.

Correlation of disease severity (as estimated by multimodal DEBM using cross-validation) with years since onset and FTD-CDR-SOB. The 2D scatter plots in subfigures A and C show the correlations of disease severity with years since onset, for symptomatic nfvPPA and bvFTD subjects, respectively. The 2D scatter plot in subfigures B and D show the correlations of disease severity with FTD-CDR-SOB. The plot on top of each subfigure shows the probability density function of the disease stages. The plots on the right of subfigures A and C show the probability density functions of years since symptom onset. The plots on the right of subfigures B and D show the probability density function of FTD-CDR-SOB. 2D, two-dimensional; bvFTD, behavioural variant frontotemporal dementia; DEBM, discriminative event-based modelling; FTD-CDR-SOB, Frontotemporal Lobar Degeneration Clinical Dementia Rating Scale Sum of Boxes; nfvPPA, non-fluent variant primary progressive aphasia.