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. 2021 Apr 15;9:e11203. doi: 10.7717/peerj.11203

Table 2. GO analysis of DEGs.

Term Description Count P-value
GO:0019080 viral gene expression 41 2.00E–13
GO:0019083 viral transcription 39 2.30E–13
GO:0000956 nuclear-transcribed mRNA catabolic process 42 2.37E–13
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 30 1.00E–11
GO:0006402 mRNA catabolic process 54 1.00E–11
GO:0006613 cotranslational protein targeting to membrane 28 2.82E–11
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 27 6.77E–11
GO:0006401 RNA catabolic process 54 2.36E–10
GO:0045047 protein targeting to ER 27 1.09E–09
GO:0070972 protein localization to endoplasmic reticulum 30 1.37E–09
GO:0072599 establishment of protein localization to endoplasmic reticulum 27 2.08E–09
GO:0016569 covalent chromatin modification 57 5.86E–09
GO:0016570 histone modification 55 9.37E–09
GO:0006612 protein targeting to membrane 33 4.53E–08
GO:0006605 protein targeting 51 1.11E–07
GO:0006338 chromatin remodeling 28 3.94E–06
GO:0090150 establishment of protein localization to membrane 40 4.60E–06
 GO:0019058 viral life cycle 39 9.44E–06
GO:1904837 beta-catenin-TCF complex assembly 11 9.72E–06
GO:0006413 translational initiation 28 1.16E–05
GO:0030522 intracellular receptor signaling pathway 33 0.000112261
GO:0043401 steroid hormone mediated signaling pathway 25 0.000193979
GO:0071383 cellular response to steroid hormone stimulus 30 0.000231361
GO:0018205 peptidyl-lysine modification 40 0.000377348
GO:0031647 regulation of protein stability 32 0.000377348
GO:0030099 myeloid cell differentiation 40 0.001113214
GO:0034332 adherens junction organization 20 0.001117253
GO:0050792 regulation of viral process 25 0.001423449
GO:0009755 hormone-mediated signaling pathway 27 0.001423449
GO:0043484 regulation of RNA splicing 19 0.001726434
GO:0043900 regulation of multi-organism process 38 0.002773222
GO:0034330 cell junction organization 30 0.003325059
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism 25 0.003664061
GO:0016573 histone acetylation 20 0.003664061
GO:0030518 intracellular steroid hormone receptor signaling pathway 18 0.003887898
GO:0019079 viral genome replication 17 0.004734418
GO:0048525 negative regulation of viral process 15 0.004893681
GO:0018393 internal peptidyl-lysine acetylation 20 0.005107113
GO:0043967 histone H4 acetylation 12 0.005107113
GO:0002181 cytoplasmic translation 15 0.005107113
GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 13 0.005220493
GO:0016331 morphogenesis of embryonic epithelium 19 0.00555893
GO:0016578 histone deubiquitination 7 0.005647965
GO:0051052 regulation of DNA metabolic process 38 0.006801205
GO:0006475 internal protein amino acid acetylation 20 0.006801205
GO:1905331 negative regulation of morphogenesis of an epithelium 6 0.007269559
GO:0042692 muscle cell differentiation 35 0.007269559
GO:0048545 response to steroid hormone 35 0.007269559
GO:0030521 androgen receptor signaling pathway 11 0.007885335
GO:0018394 peptidyl-lysine acetylation 20 0.007885335
GO:0072175 epithelial tube formation 17 0.009185473
GO:0034329 cell junction assembly 25 0.009304069
GO:1903901 negative regulation of viral life cycle 13 0.010119749
GO:0030111 regulation of Wnt signaling pathway 33 0.010318481
GO:0035148 tube formation 18 0.011328993
GO:0006473 protein acetylation 22 0.012697644
GO:0044782 cilium organization 34 0.01287833
GO:0006354 DNA-templated transcription, elongation 15 0.013214194
GO:0030177 positive regulation of Wnt signaling pathway 20 0.014794079
GO:0006984 ER-nucleus signaling pathway 9 0.014859166
GO:0045637 regulation of myeloid cell differentiation 25 0.014859166
GO:0008380 RNA splicing 39 0.014859166
GO:0034968 histone lysine methylation 15 0.014859166
GO:0001843 neural tube closure 13 0.014920111
GO:0034333 adherens junction assembly 13 0.014920111
GO:0051147 regulation of muscle cell differentiation 20 0.01537082
GO:0060606 tube closure 13 0.016202371
GO:0051348 negative regulation of transferase activity 27 0.01736378
GO:0060765 regulation of androgen receptor signaling pathway 7 0.017685114
GO:0001841 neural tube formation 14 0.018715149
GO:0032204 regulation of telomere maintenance 12 0.018715149
GO:0043901 negative regulation of muxlti-organism process 19 0.018715149
GO:0051054 positive regulation of DNA metabolic process 23 0.018715149
GO:0060271 cilium assembly 32 0.019274508
GO:0060070 canonical Wnt signaling pathway 30 0.019418493
GO:0021915 neural tube development 18 0.02189728
GO:0010171 body morphogenesis 9 0.022689191
GO:0032784 regulation of DNA-templated transcription, elongation 9 0.022689191
GO:1903311 regulation of mRNA metabolic process 29 0.02307114
GO:0044319 wound healing, spreading of cells 7 0.02307114
GO:0090505 epiboly involved in wound healing 7 0.02307114
GO:2000781 positive regulation of double-strand break repair 7 0.02307114
GO:0060766 negative regulation of androgen receptor signaling pathway 5 0.02307114
GO:0000723 telomere maintenance 18 0.02307114
GO:0000209 protein polyubiquitination 28 0.023399292
GO:1903900 regulation of viral life cycle 17 0.023399292
GO:0007044 cell-substrate junction assembly 13 0.023399292
GO:0014020 primary neural tube formation 13 0.023399292
GO:0090504 epiboly 7 0.026209669
GO:0001838 embryonic epithelial tube formation 15 0.026209669
GO:0006479 protein methylation 19 0.026209669
GO:0008213 protein alkylation 19 0.026209669
GO:0036124 histone H3-K9 trimethylation 5 0.028504092
GO:0016571 histone methylation 16 0.028504092
GO:0034976 response to endoplasmic reticulum stress 26 0.028504092
GO:0036498 IRE1-mediated unfolded protein response 10 0.028504092
GO:0046782 regulation of viral transcription 10 0.028504092
GO:0001837 epithelial to mesenchymal transition 16 0.02997652
GO:0072665 protein localization to vacuole 10 0.031694802
GO:0071824 protein-DNA complex subunit organization 26 0.031924183
GO:2000779 regulation of double-strand break repair 11 0.032301863
GO:0016049 cell growth 38 0.033335915
GO:0018023 peptidyl-lysine trimethylation 8 0.033675333
GO:0060330 regulation of response to interferon-gamma 6 0.033675333
GO:0060334 regulation of interferon-gamma-mediated signaling pathway 6 0.033675333
GO:0018022 peptidyl-lysine methylation 15 0.0339268
GO:0002011 morphogenesis of an epithelial sheet 9 0.034329329
GO:1903391 regulation of adherens junction organization 10 0.037116501
GO:0051098 regulation of binding 31 0.037419782
GO:0034504 protein localization to nucleus 24 0.037419782
GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 7 0.037419782
GO:0043543 protein acylation 23 0.039774544
GO:0055007 cardiac muscle cell differentiation 15 0.040008254
GO:1903706 regulation of hemopoiesis 37 0.040008254
GO:0006913 nucleocytoplasmic transport 29 0.040008254
GO:0006352 DNA-templated transcription, initiation 23 0.040379329
GO:0002067 glandular epithelial cell differentiation 8 0.040379329
GO:0007041 lysosomal transport 13 0.040379329
GO:0032200 telomere organization 18 0.040379329
GO:0051895 negative regulation of focal adhesion assembly 5 0.040379329
GO:0097242 amyloid-beta clearance 7 0.040379329
GO:0031503 protein-containing complex localization 25 0.040379329
GO:0007045 cell-substrate adherens junction assembly 11 0.040379329
GO:0048041 focal adhesion assembly 11 0.040379329
GO:0060560 developmental growth involved in morphogenesis 22 0.040379329
GO:0051169 nuclear transport 29 0.040822401
GO:0010172 embryonic body morphogenesis 4 0.040822401
GO:0048096 chromatin-mediated maintenance of transcription 4 0.040822401
GO:0070933 histone H4 deacetylation 4 0.040822401
GO:1900112 regulation of histone H3-K9 trimethylation 4 0.040822401
GO:0043921 modulation by host of viral transcription 6 0.04145549
GO:0052472 modulation by host of symbiont transcription 6 0.04145549
GO:0001959 regulation of cytokine-mediated signaling pathway 18 0.041669901
GO:0071156 regulation of cell cycle arrest 13 0.042842707
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 16 0.042842707
GO:0042176 regulation of protein catabolic process 31 0.042914363
GO:0006623 protein targeting to vacuole 7 0.042921458
GO:0051261 protein depolymerization 13 0.044702762
GO:0051099 positive regulation of binding 18 0.044702762
GO:0051972 regulation of telomerase activity 8 0.044702762
GO:0072666 establishment of protein localization to vacuole 8 0.044702762
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 8 0.044702762
GO:1902115 regulation of organelle assembly 19 0.044826787
GO:0050684 regulation of mRNA processing 15 0.046220077
GO:0052312 modulation of transcription in other organism involved in symbiotic interaction 6 0.046220077
GO:0051893 regulation of focal adhesion assembly 9 0.047313553
GO:0090109 regulation of cell-substrate junction assembly 9 0.047313553
GO:0015931 nucleobase-containing compound transport 22 0.047313553
GO:0051236 establishment of RNA localization 19 0.048534128
GO:0008347 glial cell migration 8 0.048610574
GO:0097193 intrinsic apoptotic signaling pathway 25 0.048695169
GO:0022625 cytosolic large ribosomal subunit 22 7.58E–12
GO:0005925 focal adhesion 54 1.22E–10
GO:0005924 cell-substrate adherens junction 54 1.22E–10
GO:0030055 cell-substrate junction 54 1.35E–10
GO:0022626 cytosolic ribosome 26 2.99E–10
GO:0015934 large ribosomal subunit 24 5.69E–08
GO:0044445 cytosolic part 34 3.89E–07
GO:0044391 ribosomal subunit 28 1.77E–06
GO:0000123 histone acetyltransferase complex 17 9.25E–06
GO:0031248 protein acetyltransferase complex 18 9.25E–06
GO:1902493 acetyltransferase complex 18 9.25E–06
GO:0035097 histone methyltransferase complex 16 5.31E–05
GO:0016363 nuclear matrix 18 6.56E–05
GO:0034399 nuclear periphery 19 0.0002262
GO:0070603 SWI/SNF superfamily-type complex 14 0.0002262
GO:0042788 polysomal ribosome 9 0.000278795
GO:0098984 neuron to neuron synapse 34 0.000596952
GO:0014069 postsynaptic density 32 0.000714655
GO:0032279 asymmetric synapse 32 0.000864164
GO:0030496 midbody 21 0.000875088
GO:0005840 ribosome 28 0.000907132
GO:0000790 nuclear chromatin 35 0.000907132
GO:0099572 postsynaptic specialization 33 0.000926357
GO:1904949 ATPase complex 15 0.000926357
GO:0034708 methyltransferase complex 16 0.000926357
GO:0005667 transcription factor complex 34 0.000926357
GO:0016607 nuclear speck 36 0.000940948
GO:0005938 cell cortex 30 0.001070189
GO:0101002 ficolin-1-rich granule 21 0.001630215
GO:0044798 nuclear transcription factor complex 22 0.001853344
GO:0000812 Swr1 complex 5 0.002106877
GO:0000118 histone deacetylase complex 10 0.004130179
GO:0042470 melanosome 14 0.004493787
GO:0048770 pigment granule 14 0.004493787
GO:0005844 polysome 11 0.005579034
GO:0090575 RNA polymerase II transcription factor complex 18 0.005891446
GO:1904813 ficolin-1-rich granule lumen 15 0.006649382
GO:1902562 H4 histone acetyltransferase complex 8 0.00862081
GO:0031252 cell leading edge 33 0.00862081
GO:0005643 nuclear pore 12 0.00862081
GO:0005635 nuclear envelope 36 0.012865041
GO:0099092 postsynaptic density, intracellular component 5 0.013474404
GO:0030027 lamellipodium 19 0.014296793
GO:0070461 SAGA-type complex 6 0.017456175
GO:0044455 mitochondrial membrane part 21 0.018871465
GO:0099091 postsynaptic specialization, intracellular component 5 0.026165033
GO:0044666 MLL3/4 complex 4 0.026793714
GO:0005913 cell-cell adherens junction 13 0.026869727
GO:0000792 heterochromatin 10 0.028802567
GO:0099738 cell cortex region 7 0.028802567
GO:0031965 nuclear membrane 24 0.041189729
GO:0000124 SAGA complex 4 0.042262875
GO:0071565 nBAF complex 4 0.042262875
GO:0044309 neuron spine 16 0.045301703
GO:0017053 transcriptional repressor complex 10 0.045301703
GO:0097346 INO80-type complex 5 0.04846594
GO:0016605 PML body 11 0.048596868
GO:0003713 transcription coactivator activity 44 1.54E–07
GO:0035257 nuclear hormone receptor binding 26 5.03E–06
GO:0045296 cadherin binding 41 5.22E–06
GO:0051427 hormone receptor binding 27 4.05E–05
GO:0003735 structural constituent of ribosome 28 5.75E–05
GO:0050839 cell adhesion molecule binding 49 0.000164258
GO:0061659 ubiquitin-like protein ligase activity 28 0.000564585
GO:0061630 ubiquitin protein ligase activity 27 0.000675924
GO:0042393 histone binding 25 0.000675924
GO:0047485 protein N-terminus binding 17 0.001209051
GO:0019787 ubiquitin-like protein transferase activity 39 0.001859565
GO:0035258 steroid hormone receptor binding 15 0.001859565
GO:0004842 ubiquitin-protein transferase activity 36 0.004671669
GO:0003730 mRNA 3’-UTR binding 14 0.005656635
GO:0030374 nuclear receptor transcription coactivator activity 11 0.016358235
GO:0031267 small GTPase binding 38 0.016779445
GO:0017016 Ras GTPase binding 37 0.016779445
GO:0044389 ubiquitin-like protein ligase binding 29 0.016779445
GO:0001085 RNA polymerase II transcription factor binding 18 0.017774698
GO:0003714 transcription corepressor activity 24 0.017774698
GO:0033613 activating transcription factor binding 12 0.024777396
GO:0031625 ubiquitin protein ligase binding 27 0.024777396
GO:0042800 histone methyltransferase activity (H3-K4 specific) 5 0.024777396
GO:0003779 actin binding 36 0.026046781
GO:0005088 Ras guanyl-nucleotide exchange factor activity 16 0.026427777
GO:0004402 histone acetyltransferase activity 10 0.026427777
GO:0046965 retinoid X receptor binding 5 0.027715133
GO:0055106 ubiquitin-protein transferase regulator activity 5 0.027715133
GO:0050681 androgen receptor binding 8 0.028197009
GO:0061733 peptide-lysine-N-acetyltransferase activity 10 0.029296991
GO:0042974 retinoic acid receptor binding 6 0.031275892
GO:0005089 Rho guanyl-nucleotide exchange factor activity 11 0.032203632
GO:0016887 ATPase activity 32 0.037839109
GO:0070577 lysine-acetylated histone binding 5 0.038501268
GO:0140033 acetylation-dependent protein binding 5 0.038501268
GO:0070491 repressing transcription factor binding 10 0.043198409
GO:0016922 nuclear receptor binding 5 0.044382275
GO:0001098 basal transcription machinery binding 10 0.044382275
GO:0001099 basal RNA polymerase II transcription machinery binding 10 0.044382275
GO:0016407 acetyltransferase activity 13 0.04501654