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. Author manuscript; available in PMC: 2022 Mar 25.
Published in final edited form as: N Engl J Med. 2021 Mar 25;384(12):1160–1162. doi: 10.1056/NEJMcibr2035081

Figure 1. Obesity and the Tumor Immune Microenvironment.

Figure 1.

Obesity reshapes the metabolism of cancer cells to impair T-cell inflammatory functions. Obesity remodels the cellular fuel use of tumors to increase cancer-cell fatty acid oxidation while reducing the numbers and spatial positioning of CD8+ T cells to reduce antitumor immunity. A “multi-omic” approach showed that PHD3 is a candidate to mediate these effects because decreased PHD3 expression led to greater lipid metabolism and T-cell suppression.