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NSP14/NSP10 substrate specificity and reaction mechanism. (A) NSP14/NSP10 activity on the Exo control substrate results primarily in one product. (B) Sequences of distinct RNA substrates that pair with the Exo template. Asterisks represent PO bonds. (C) NSP14/NSP10 activity measured by SAMDI-MS on RNA substrates in B. (D) The NSP14 D273A mutant is not active against the Exo control substrate. All measurements are from triplicate data.
