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. 2021 Apr 12;14:2475–2488. doi: 10.2147/OTT.S293180

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© 2021 Huang et al.

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Circ_0006168 silencing-mediated effects are largely overturned by the silencing of miR-516b-5p or the overexpression of XBP1 in ESCC cells. (A–E) Eca109 and KYSE150 cells were transfected with si-NC, si-circ_0006168, si-circ_0006168 + inhibitor-NC, si-circ_0006168 + inhibitor-miR-516b-5p, si-circ_0006168 + pcDNA or si-circ_0006168 + XBP1. (A) The migration rate of ESCC cells was analyzed by wound healing assay. (B and C) Transwell assays were performed to analyze cell migration and invasion abilities. (D) MTT assay was utilized to analyze cell proliferation ability. (E) Colony formation assay was used to analyze cell proliferation capacity. **P<0.01, ***P<0.001.