Table 2.
Univariable and multivariable analysis of factors associated with 30-day mortality in the entire study cohort (n = 505). Odds ratios from a logistic regression model: analyzing each variable separately and adjusted for all the given variables
| Variable | Alive N = 437 (86.5%) |
Dead N = 68 (13.5%) |
Univariable OR (95% CI) | Univariable p | Multivariable OR (95% CI) | Multivariable p |
|---|---|---|---|---|---|---|
| Male gender | 282 (64.5%) | 49 (72.1%) | 1.418 (0.806–2.493) | 0.226 | 1.550 (0.750–3.202) | 0.237 |
| Age, mean (95% CI) | 62.3 (60.4–64.3) | 63.5 (58.8–68.2) | 1.015 (1.001–1.029) | 0.035 | NAa | NAa |
| Age group | ||||||
| < 50 | 128 (29.3%) | 12 (17.6%) | Reference | Reference | ||
| 50–64 | 128 (29.3%) | 19 (27.9%) | 1.583 (0.738–3.396) | 0.238 | 1.452 (0.565–4) | 0.438 |
| 65–79 | 114 (26.1%) | 21 (30.9%) | 1.965 (0.926–4.172) | 0.079 | 3.405 (1.197–9.684) | 0.022 |
| ≥ 80 | 67 (15.3%) | 16 (23.5%) | 2.547 (1.139–5.696) | 0.023 | 5.881 (1.740–19.870) | 0.004 |
| Admission GCS | ||||||
| 13–15 | 294 (67.3%) | 16 (23.5%) | Reference | Reference | ||
| 9–12 | 51 (11.7%) | 7 (10.3%) | 2.522 (0.989–6.435) | 0.053 | 2.634 (0.901–7.703) | 0.077 |
| 3–8 | 92 (21.1%) | 45 (66.2%) | 8.988 (4.851–16.652) | < 0.001 | 15.351 (6.894–34.185) | < 0.001 |
| Hypertension | 142 (32.5%) | 21 (30.9%) | 0.928 (0.534–1.612) | 0.791 | 0.793 (0.370–1.697) | 0.550 |
| Atrial fibrillation | 55 (12.6%) | 15 (22.1%) | 1.966 (1.037–3.725) | 0.038 | 1.653 (0.638–4.296) | 0.300 |
| Coronary heart disease | 49 (11.2%) | 14 (20.6%) | 2.053 (1.062–3.967) | 0.032 | 2.004 (0.792–5.072) | 0.142 |
| Alcohol abuse | 122 (27.9%) | 26 (38.2%) | 1.598 (0.939–2.721) | 0.084 | 1.964 (0.917–4.205) | 0.082 |
| Coagulopathy | 167 (38.2%) | 39 (57.4%) | 2.174 (1.295–3.649) | 0.003 | 1.572 (0.729–3.391) | 0.249 |
| Thrombocyte level (100 × 109/L), mean (95% CI) | 210 (192–228) | 186 (153–220) | 0.993 (.989–0.997) | < 0.001 | NAa | NAa |
| INR value, mean (95% CI) | 1.9 (1.7–2.1) | 2.4 (1.6–3.3) | 1.249 (0.928–1.680) | 0.142 | NAa | NAa |
| Thromboplastin time (%), mean (95% CI) | 60 (52–69) | 49 (31–67) | 0.985 (0.975–0.994) | 0.001 | NAa | NAa |
| Coagulopathy correction | 152 (34.8%) | 30 (44.1%) | 1.480 (0.882–2.484) | 0.137 | 0.725 (0.340–1.545) | 0.404 |
| Hematoma evacuation | 248 (56.8%) | 24 (35.3%) | 0.416 (0.244–0.708) | 0.001 | 0.138 (0.061–0.316) | < 0.001 |
| Ventriculostomy | 11 (2.5%) | 3 (4.4%) | 1.787 (0.486–6.578) | 0.382 | 2.824 (0.626–12.737) | 0.177 |
| Hemorrhage volume (mL), mean (95% CI) | 111.9 (102.0–121.8) | 142.0 (113.2–170.7) | 1.004 (1.001–1.006) | 0.002 | NAa | NAa |
| Hemorrhage volume (mL) | ||||||
| 0–50 | 201 (46.0%) | 19 (27.9%) | Reference | Reference | ||
| 51–100 | 55 (12.6%) | 13 (19.1%) | 2.500 (1.162–5.378) | 0.019 | 2.689 (1.027–7.039) | 0.044 |
| 101–200 | 109 (24.9%) | 18 (26.5%) | 1.747 (0.880–3.467) | 0.111 | 3.807 (1.415–10.241) | 0.008 |
| > 200 | 72 (16.5%) | 18 (26.5%) | 2.645 (1.315–5.318) | 0.006 | 4.477 (1.562–12.836) | 0.005 |
OR, odds ratio; p, p-value; CI, confidence interval; GCS, Glasgow Coma Scale. NAa = not included in the regression model due to categorized parameter of the same value