Table 3.
Univariable and multivariable analysis of factors associated with 30-day mortality in the coagulopathy subcohort (n = 206). Odds ratios from a logistic regression model: analyzing each variable separately and adjusted for all the given variables
| Variable | Alive N = 167 (81.1%) |
Dead N = 39 (18.9%) |
Univariable OR (95% CI) | Univariable p | Multivariable OR (95% CI) | Multivariable p |
|---|---|---|---|---|---|---|
| Male gender | 109 (65.3%) | 28 (71.8%) | 1.354 (0.629–2.916) | 0.438 | 1.367 (0.519–3.602) | 0.527 |
| Age, mean (95% CI) | 66.9 (64.4–69.4) | 68.3 (62.2–74.5) | 1.005 (0.984–1.027) | 0.629 | NAa | NAa |
| Age group | ||||||
| < 50 | 24 (14.4%) | 3 (7.7%) | Reference | Reference | ||
| 50–64 | 37 (22.2%) | 10 (25.6%) | 2.162 (0.539–8.670) | 0.276 | 2.791 (0.486–16.016) | 0.250 |
| 65–79 | 68 (40.7%) | 14 (35.9%) | 1.647 (0.435–6.234) | 0.462 | 4.459 (0.756–26.316) | 0.099 |
| ≥ 80 | 38 (22.8%) | 12 (30.8%) | 2.526 (0.646–9.887) | 0.183 | 8.492 (1.189–60.627) | 0.033 |
| Admission GCS | ||||||
| 13–15 | 116 (69.5%) | 14 (35.9%) | Reference | Reference | ||
| 9–12 | 20 (12.0%) | 6 (15.4%) | 2.486 (0.855–7.230) | 0.095 | 2.342 (0.690–7.947) | 0.172 |
| 3–8 | 31 (18.6%) | 19 (48.7%) | 5.078 (2.291–11.257) | < 0.001 | 6.476 (2.291–18.302) | < 0.001 |
| Hypertension | 74 (44.3%) | 16 (41.0%) | 0.874 (0.431–1.774) | 0.710 | 0.633 (0.259–1.548) | 0.316 |
| Atrial fibrillation | 49 (29.3%) | 15 (38.5%) | 1.505 (0.728–3.111) | 0.270 | 1.536 (0.574–4.112) | 0.393 |
| Coronary heart disease | 39 (23.4%) | 14 (35.9%) | 1.838 (0.872–3.876) | 0.110 | 2.492 (0.972–6.393) | 0.057 |
| Alcohol abuse | 49 (29.3%) | 14 (35.9%) | 1.349 (0.647–2.810) | 0.425 | 2.370 (0.797–7.049) | 0.121 |
| Thrombocyte level (100 × 109/L), mean (95% CI) | 208 (184–231) | 184 (144–224) | NAb | NAb | NAb | NAb |
| INR value, mean (95% CI) | 2.3 (2.0–2.5) | 2.8 (1.7–3.8) | NAb | NAb | NAb | NAb |
| Thromboplastin time (%), mean (95% CI) | 43 (35–50) | 37 (21–52) | NAb | NAb | NAb | NAb |
| Coagulopathy correction | 91 (54.5%) | 24 (61.5%) | 1.336 (0.655–2.727) | 0.426 | 1.166 (0.453–3.001) | 0.750 |
| Hematoma evacuation | 108 (64.7%) | 16 (41.0%) | 0.380 (0.186–0.775) | 0.008 | 0.214 (0.068–0.675) | 0.008 |
| Ventriculostomy | 3 (1.8%) | 3 (7.7%) | 4.556 (0.883–23.495) | 0.070 | 11.941 (1.602–89.020) | 0.016 |
| Hemorrhage volume (mL), mean (95% CI) | 119.4 (104.5–134.4) | 127.8 (91.8–163.7) | 1.001 (0.997–1.004) | 0.639 | NAa | NAa |
| Hemorrhage volume (mL) | ||||||
| 0–50 | 57 (34.1%) | 12 (30.8%) | Reference | Reference | ||
| 51–100 | 17 (10.2%) | 6 (15.4%) | 1.676 (0.547–5.137) | 0.366 | 0.643 (0.167–2.470) | 0.520 |
| 101–200 | 56 (33.5%) | 11 (28.2%) | 0.933 (0.380–2.289) | 0.880 | 1.342 (0.343–5.246) | 0.672 |
| > 200 | 37 (22.2%) | 10 (25.6%) | 1.284 (0.504–3.272) | 0.601 | 1.482 (0.367–5.982) | 0.432 |
OR, odds ratio; p, p-value; CI, confidence interval; GCS, Glasgow Coma Scale. NAa = not included in the regression model due to categorized parameter of the same value, NAb = not analyzed due to medication itself being defining factor for the coagulopathy