Figure 1.

A. 5-fraction bladder dose and late urinary flare (Kole et al). (i) Mean cumulative whole bladder DVH’s for patients with (dashed line) and without (solid line) late urinary flare. (ii) LKB model of the probability of late urinary flare vs. bladder EUD. The figures in both panels were taken from the original publication.

B. 4-fraction urethra dose and late ≥ grade 2 urinary toxicity (Zhang et al). Probit models of the probability of late ≥ grade 2 urinary vs. different dose metrics to urethra: (i) D1cc, (ii) D0.1cc and (iii) Dmax. Patients with (marked by open squares) and without (black circles) toxicity are shown at the top and bottom of the plot, respectively. Fitting of the data to the probit model was performed by the authors of the current report using individual patient DVHs provided by the original publication, with a conversion to 5-fraction equivalent dose.

C. 5-fraction rectum dose and late ≥ grade 3 bowel toxicity (Kim et al). Probit models of the probability of late ≥ grade 3 rectal toxicity vs. different rectum circumference doses: (i) C24Gy, (ii) C39Gy and (iii) volume of rectal wall V50Gy. Patients with (marked by open squares) and without (black circles) toxicity are shown at the top and bottom of the plot, respectively. The fitting of the data to the probit model was performed by the authors of the present report using the data shown in Fig. 1 of the original publication.