. Author manuscript; available in PMC: 2022 May 1.

Published in final edited form as: Int J Radiat Oncol Biol Phys. 2020 Dec 22:S0360-3016(20)34356-X. doi: 10.1016/j.ijrobp.2020.09.054

Table 4.

Examples of dose constraints used in the authors’ institutions and on clinical trials

	Georgetown^* (35–36.25 / 5 fx, over 2 weeks)	UNC (NCT 00643617)^* (38 Gy / 4 fx over 4 days)	RTOG 0938⁵⁵ (36.25 Gy / 5 fx over 2.5 weeks)	NRG GU-005⁵⁶ (36.25 Gy / 5 fx over 2.5 weeks)
PTV	≤ 125% prescription dose		D0.03cc ≤ 38.78 Gy (Linac) D0.03cc ≤ 43.5 Gy (CyberKnife)	Dmax ≤ 38.78 Gy
Prostatic urethra	V42Gy ≤ 0.03 cc	Dmax < 40 Gy	D0.03cc ≤ 38.78 Gy	D0.03cc ≤ 38.78 Gy
Bladder	V37Gy ≤ 5 cc	Dmax < 45.6 Gy D10cc < 41.8 Gy	D1cc ≤ 38.06 Gy D10% ≤ 32.63 Gy D50% ≤ 18.13 Gy	D0.03cc ≤ 38.06 Gy D10% ≤ 18.12 Gy
Rectum	V36Gy ≤ 1 cc	Dmax < 38 Gy	D1cc ≤ 38.06 Gy D3cc ≤ 34.4 Gy D10% ≤ 32.63 Gy D20% ≤ 29 Gy D50% ≤ 18.13 Gy	D0.03cc ≤ 38.06 Gy D3cc ≤ 34.4 Gy D10% ≤ 32.63 Gy D20% ≤ 29 Gy D50% ≤ 18.13 Gy
Penile bulb	V29.5 Gy ≤ 3 cc		Dmax ≤ 36.25 Gy D3cc ≤ 20 Gy	D0.03cc ≤ 36.25 Gy D3cc ≤ 19.9 Gy

Abbreviations: OAR; organ at risk, fx; fractions

Note: Bladder and rectum volumes are defined as solid organs. For RTOG 0938 and NRG GU-005, the rectum is defined as extending 15cm from the anus or to the rectosigmoid flexure.

Dosimetric parameters currently used at authors’ institutions