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. 2020 Jul 31;9(1):31–41. doi: 10.1016/j.prnil.2020.07.002

Fig. 6.

Fig. 6

Immunohistochemistry of removed prostate cancer tumors. (A)–(D) H&E staining of induced prostate cancer two weeks after the implantation of PC3 cells into the flanks of the mice. (A) Tumors in PC3-transplanted mice (X100), Inset: (X400). The tumor is well-demarcated from the dermal tissue and composed of closely packed cancer cells. (B) Tumors in PC3-transplanted mice after 13.5 mg/kg/day CPT-11 systemic treatment (X100). (C) Tumors in PC3-transplanted mice after hTERT-ADSC.sTRAIL systemic treatment (X100). (D) Tumors in PC3-transplanted mice after hTERT-ADSC.sTRAIL combined with 13.5 mg/kg/day CPT-11 systemic treatment (X100). Geographic necrosis was seen. The neoplastic cells remaining in the peripheral lesion were shrunken and had distinct borders. (E), (F) TRAIL immunohistochemical staining of tumors after treatment shows anti-TRAIL–positive cells. (E) Tumors in the PC3-transplanted mice after hTERT-ADSC.sTRAIL systemic treatment (X100), Inset: (X400). (F) Tumors in PC3-transplanted mice after hTERT-ADSC.sTRAIL combined with 13.5 mg/kg/day CPT-11 systemic treatment (X100), Inset: (X400) (G), (H) TUNEL immunohistochemical staining of tumors after treatment shows TUNEL-positive cells. (G) Tumors in PC3-transplanted mice after hTERT-ADSC.sTRAIL systemic treatment (X100), Inset: (X400). (H) Tumors in PC3-transplanted mice after hTERT-ADSC.sTRAIL combined with 13.5 mg/kg/day CPT-11 systemic treatment (X100), Inset: (X400). Hyperchromatic nuclei are centrally located with condensed eosinophilic cytoplasm, which have apoptotic bodies. Inset: Apoptotic cells with apoptotic bodies. Bar. 500 μm. H&E = hematoxylin & eosin, TUNEL = terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling.