Figure 1.

Simplified maps of the parental monomer pDNA p(3NF₁-Luc-3NF₂)m and its monomer or concatemer derivatives

(A–F) Optimized NF-κB DNA nuclear targeting sequences (DTSs) named 3NF₁ and 3NF₂ sequences, respectively, upstream and downstream of the luciferase gene are shown as dark arrowheads. Scramble sequences named Scr₁ and Scr₂ are shown as light gray arrowheads. The ampicillin resistance gene AmpR, the luciferase cassette, and the strong ubiquitous CMV promoter are shown as green, orange, and blue arrows.