Table 1.
Summary of the most common irAEs in different organs and systems.
| Organs and systems | Most common irAEs | Typical occurrence (weeks) | Incidence (%) |
|---|---|---|---|
| Gastrointestinal | Diarrhea | 6 | 19–33 |
| Colitis | 6 | 7 | |
| Hepatitis | 8–14 | 5–10 | |
| Dermatological | Rash | 2–3 | 50 |
| Pruritus | 2–3 | 50 | |
| Endocrinological | Hypothyroidism | 5 | 6 |
| Hypophysitis | 8 | <5 | |
| Pneumological | Pneumonitis | 12 | 5 |
| Rheumatological | Arthritis | 20 | 7 |
| Cardial | (Peri-)myocarditis | Mostly first few months | <1 |
| Arrhythmias | Mostly first few months | <1 | |
| Hematological | (Hemolytic) anemia | No data | 5–10 |
| Ocular | Uveitis | 8 | <1 |
| Nephrological | Interstitial nephritis | 8–40 | 2–5 |
| Neurological | Headache | No data | 6–12 |
| Myasthenia gravis | 13 | <1 |
irAE, immune-related adverse event.