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Randomization and treatment schedule. M, C, ASS (BR) arm: initial BR followed by cisplatin-pemetrexed chemotherapy combined with bevacizumab for eligible patients; ChT arm: cisplatin-pemetrexed ChT combined with bevacizumab for eligible patients with BR only at cerebral disease progression.
ASS, assessment; BR, brain radiotherapy; C, cycle of chemotherapy; ChT, chemotherapy; M, chemotherapy maintenance; R, randomization.
