Table 1.

Review of literature. Sensitivity and specificity of brush cytology and FISH analysis in sporadic and PSC-associated CCA.

Author	No. of brush samples	Brush cytology		FISH
		Sensitivity (%)	Specificity (%)	Sensitivity (%)	Specificity (%)	Analysis
Bang et al.26	114	75	100
Bardales et al.84	38	75	93
Baron et al.85	110	18	98
Binek et al.86	89	67	92
Chaiteerakij et al.87	99	38	100	55	100
De Peralta-Venturina et al.88	74	89	96
Desa et al.89	24	40	NR
Eiholm et al.93	75	66	100
Elek et al.90	103	53	100
Farrell et al.94	46	57	80
Ferrari et al.95	74	56	100
Fritcher et al.91	284	15	100	44	81	Polysomy or trisomy 7
Fritcher et al.97	498	20	99	43	99
Fritcher et al.92	272	19	100	65	93	Probes 1q21, 7p12, 8q24, and 9p21
Foutch et al.96	7	57	100
Glasbrenner et al.98	86	56	91
Gonda et al.99	100	32	100	51	100	FISH + cytology
Govil et al.100	278	68	100
Hamada et al.101	60	57	100
Harewood et al.102	113	18	100
Howell et al.103	28	58	100
Kipp et al.104	131	15	98	34	91
Kitajima et al.105	51	73	100
Kocjan and Smith106	267	44	100
Kurzawinski et al.107	100	69	100
Kushnir et al.108	101	26	98	39	100	HGD samples included
Layfield et al.109	108	44	98
Lee et al.110	149	37	100
Liew et al.111	30	54	82	31	100
Logrono et al.112	183	48	98
Macken et al.113	123	63	96
Mahmoudi et al.114	199	61	98
Mehmood et al.73	142	65	100
Mohammad Alizadeh et al.115	105	33	100
Ponchon et al.35	210	35	97
Pugliese et al.116	22	73	100
Pugliese et al.36	42	53	100
Rabinovitz et al.117	65	40	100
Rösch et al.118	50	46	100
Ryan119	69	44	100
Salomao et al.120	73	40	94	64	94
Schoefl et al.121	65	47	100
Scudera et al.122	25	50	100
Singhi et al.123	132	35	98
Smoczynski et al.128	81	35	100	52	89
Sugiyama et al.124	43	48	100
Weber et al.40	58	41	100
Zhai125	22	14	100	55	62
PSC-associated CCA
Bangarulingam et al.82	235			72	57	Polysomy or trisomy 3/7
Boberg et al.75	61	73	95
Charatcharoenwitthaya et al.126	230	46	97	88	73	Polysomy or trisomy
Furmanczyk et al.76	107	63	100
Halme et al.127	102	58	62
Lal et al.77	21	67	94
Levy et al.8	34	7	100	29	100
Lindberg et al.78	20	71	100
Moreno Luna et al.79	86	18	100	70	86
Ponsioen et al.80	47	60	89
Singhi et al.123	37	8	100
Siqueira et al.81	318	46	100
Von Seth et al.83	208			80	74	FISH + cytology

CCA, cholangiocarcinoma; FISH, fluorescence in situ hybridization; HGD, high grade dysplasia; NR, not reported; PSC, primary sclerosing cholangitis.