Qualitative organoid fluid metabolomics. (A) Venn diagram depicting the number of metabolites identified in organoid CM, MCM, IOF, and EOF across donors. (B) IOF metabolite presence by donor, in addition to (C) the mean superpathway breakdown of the IOF metabolites common to all donors. (D) EOF metabolite presence by donor, in addition to (E) the mean superpathway breakdown of the EOF metabolites common to all donors. (F) The 17 IOF-exclusive metabolites, arranged by pathway, wherein italicized metabolites are predicted.