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. 2021 Apr 5;118(15):e2026804118. doi: 10.1073/pnas.2026804118

Fig. 4.

Fig. 4.

Quantitative intraorganoid fluid metabolomics. (A) Principal component analysis of IOF and EOF quantitative metabolic profiles from each donor in addition to the number of metabolites elevated (P ≤ 0.05) in each. (B) EOF metabolomic signatures by donor (relative concentration [RC]). (C) Corresponding EOF donor vs. donor statistical comparisons [P ≤ 0.0001 (****)] are also provided. (D) Mean total metabolite levels in EOF by donor. (E) IOF metabolomic signatures by donor. (F) Corresponding IOF donor vs. donor statistical comparisons [P ≤ 0.01 (**)] are also provided. (G) Mean total metabolite levels in IOF by donor (not significant [NS]). (H) Network view by pathway of the metabolites elevated (P ≤ 0.05) in IOF vs. EOF wherein node diameter is proportional to fold-change magnitude.