Fig. 2.

Dose-dependent responses of SARS-CoV-2 replicon reporter activity to GS-441524 and GC376. The 293T cells were electroporated with T7 polymerase transcribed replicon RNA and incubated with GS-441524 or GC376 compounds at indicated concentrations. The activities were determined by percentage of GFP or luciferase signals comparing to DMSO-treated cells (A–D). The cytotoxicity of GS-441524 and GC376 to the cells were also examined (E and F).