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Conserved dimerization mode of hGBPs. (A) The calculated scattering curve using the crystal structure of hGBP51–486 in complex with GDP ⋅ AlF3 is in agreement with the SAXS data. (B) The crystal structure fits the SAXS envelope. (C) hGBP1FL, hGBP2FL, and hGBP5FL have similar scattering curves. (D) The SAXS data support a closed conformation of hGBP5FL in solution.
