Figure 2.

Knockdown of circ_0001018 significantly suppressed the growth of tumors in vivo

(A) TPC-1 cells with empty vectors (NC) or circ_0001018 knockdown vectors (sh-circ_0001018) were injected into nude mice. The representative images were obtained using a small imaging system at week 1 and week 4. (B) The total radiance flux was monitored to represent tumor formation after the mice were injected (for 4 weeks). ∗p < 0.05, ∗∗p < 0.01, versus the NC group. Data indicate the mean ± SD. NC mice = 5, sh-circRNA mice = 5; repetition = 3. (C) Representative images of xenograft tumors obtained from six nude mice. (D) Representative images of H&E pathological staining. (E) The number of proliferating cells were detected by a Ki67 IHC assay. Data indicate the mean ± SD. NC mice = 5, sh-circRNA mice = 5; repetition = 3.